Generic name: Glyburide

Why is this medication prescribed?
Glyburide is used to treat type 2 (noninsulin-dependent) diabetes (formerly 'adult-onset'), particularly in people whose diabetes cannot be controlled by diet alone. Glyburide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Glyburide is not used to treat type 1 (insulin-dependent) diabetes (formerly 'juvenile-onset').

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?
Glyburide comes in tablets to take by mouth. It usually is taken once a day with breakfast or twice a day (when a large daily dose is required). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glyburide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take glyburide even if you feel well. Do not stop taking glyburide without talking to your doctor.

What special precautions should I follow?
Before taking glyburide,

• tell your doctor and pharmacist if you are allergic to glyburide or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), dexamethasone (Decadron), diuretics ('water pills'), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], medications for high blood pressure or heart disease, metformin (Glucophage), niacin (nicotinic acid), oral contraceptives, phenytoin (Dilantin), prednisone, probenecid (Benemid), and vitamins.
• tell your doctor if you have or have ever had heart or kidney disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking glyburide, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glyburide.
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
• remember that alcohol can add to the drowsiness caused by this drug.
• tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of glyburide.
• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Glyburide may make your skin sensitive to sunlight.

What special dietary instructions should I follow?
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet. Alcohol increases blood sugar; ask your doctor for information on how much is safe to drink.

What should I do if I forget a dose?
Before you start taking glyburide, ask your doctor what to do if you forget to take a dose. Write these directions down so you can refer to them later.

As a general rule, take the missed dose as soon as you remember it unless it is almost time for the next dose. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?
Although side effects from glyburide are not common, they can occur. If you have any of these symptoms, eat or drink a food or beverage with sugar in it, such as hard candy or fruit juice, and call your doctor immediately; symptoms of low blood sugar (hypoglycemia) include:

• shakiness
• dizziness
• rapid heartbeat
• sweating or confusion
• blurred vision
• headache
• numbness or tingling of the mouth
• weakness
• fatigue
• pale color
• sudden hunger

If you have any of these symptoms, call your doctor immediately; symptoms of high blood sugar (hyperglycemia) include:

• thirst
• dry mouth
• tiredness
• flushing
• dry skin
• frequent urination
• loss of appetite
• trouble breathing

If you experience any of the following symptoms, call your doctor immediately:

• seizures
• loss of consciousness
• skin rash
• itching or redness
• exaggerated sunburn
• yellowing of the skin or eyes
• light-colored stools
• dark urine
• unusual bleeding or bruising
• fever
• sore throat

What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose
In case of overdose, call your local poison controlcenter at 1-800-222-1222. If the victim has collapsedor is not breathing, call local emergency services at911.

What other information should I know?
Studies have shown that people who take oral antidiabetic drugs have a higher rate of death caused by heart problems than people whose diabetes is treated with diet and insulin. Talk to your doctor about the possible risks, benefits, and alternatives of taking glyburide for your condition.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to glyburide.

To monitor the effectiveness of glyburide, measure the amount of sugar (glucose) in your blood or urine (when blood sugar is above a certain high level, you will have sugar in your urine). For these measurements, you will need special paper tapes, tablets, or plastic strips that change color depending on how much sugar is present. You also can use a blood glucose meter to measure the amount of sugar in your blood. Your doctor also may ask you to test your urine for ketones (substances present when diabetes is not under control). Follow your doctor's directions for testing your urine and blood and for recording the results. If your blood sugar is high or if sugar or ketones are present in your urine, call your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.